Juventus have lost their first game without Cristiano Ronaldo.
The Serie A giants conceded one goal against Empoli leaving them with only one point and no wins since the start of the season.
Juve’s defeat comes after Manchester United agreed to re-sign Cristiano Ronaldo.
Leonardo Mancuso’s first-half goal was enough to give Empoli only their second top-flight win over the 36-time champions, who were disappointing.
Juve finished fourth in Serie A last season and began this campaign by letting a two-goal lead over Udinese slip, ending with a 2-2 draw after Ronaldo had asked to be left out of the starting XI.
On Saturday, Massimiliano Allegri’s side posed little threat in front of the Empoli goal, with Manuel Locatelli pulling a shot wide deep into stoppage time.
Mancuso, 29, who spent 18 months at Juve without ever playing for the first team, had volleyed in from close range after 21 minutes.
Empoli hung on to claim their first win over Juve in the league since 1999.